Radiprodil (RGH-896)
Radiprodil
CAS: 496054-87-6
Molecular Formula: C21H20FN3O4
Radiprodil (RGH-896) - Names and Identifiers
Radiprodil (RGH-896) - Physico-chemical Properties
| Molecular Formula | C21H20FN3O4 |
| Molar Mass | 397.41 |
| Density | 1.394±0.06 g/cm3(Predicted) |
| Melting Point | 223-225 °C |
| Solubility | DMSO: 220 mg/mL (553.6 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| pKa | 8.62±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Use | Radiprodil (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
| Target | NR2B |
Radiprodil (RGH-896) - Reference
| Reference Show more | 1. Labas R, et al. Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors. Eur J Med Chem. 2011 Jun;46(6):2295-309.2. Rammes G, et al. The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP). Neuropharmacology. 2018 Sep 15;140:184-192.3. Mullier B, et al. GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors. Neuropharmacology. 2017 Sep 1;123:322-331. |
Radiprodil (RGH-896) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.516 ml | 12.582 ml | 25.164 ml |
| 5 mM | 0.503 ml | 2.516 ml | 5.033 ml |
| 10 mM | 0.252 ml | 1.258 ml | 2.516 ml |
| 5 mM | 0.05 ml | 0.252 ml | 0.503 ml |
Last Update：2024-01-02 23:10:35
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